Call for Abstracts and Travel Awards: All authors notified by email  ︎  18 invited speakers confirmed  ︎  Save your seat! Register here until October 7  ︎  Check the programme at a glance  ︎  Interested in joining the team of volunteers? Apply now!   ︎  Become a partner of #CRSy22  ︎ 





︎  Time in Lisbon (WEST)



8:30

Registration




10:00

Opening Remarks




10:30

Keynote Lecture

Shahin Rafii, MD
Weill Cornell Medicine



11:30

Coffee Break




12:00

MCP-1-CCR2/4 axis plays a crucial role in astrocyte-breast cancer interactions facilitating brain metastasis


Sahar Israeli Dangoor, PhD Candidate
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University



12:15

Uncovering the mechanisms leading to Basal Cell Carcinoma initiation


Sara Canato, PhD
Postdoc @Champalimaud Foundation



12:30

Mechanisms of longevity and cancer resistance in long-lived mammals


Vera Gorbunova, PhD
Department of Biology, University of Rochester
Rochester Aging Research Center




13:00

Lunch




14:30

Jacky G. Goetz, PhD
INSERM - National Institute of Health and Medical Research



15:00

Yasuyuki Fujita, PhD
Graduate School of Medicine, Kyoto University



15:30

Neuron-glial interactions in health and disease: from cognition to cancer


Michelle Monje, MD, PhD
Stanford University
Howard Hughes Medical Institute




16:00

Delta One T cells: a new adoptive cell therapy for cancer


Bruno Silva-Santos, PhD
Faculdade de Medicina da Universidade de Lisboa 
Instituto de Medicina Molecular (iMM)




16:30

Coffee Break




17:00
Networking 

Meet the speaker


Meet the invited speakers in small groups and discuss your questions on research or career in 10 minute slots.



18:00

Social
C
CU guided tours


Explore the Champalimaud Centre for the Unknown in a guided tour to the building, including a visit to the labs and stories about the Champalimaud Research culture.






︎  Time in Lisbon (WEST)



9:00

Registration




9:30

Keynote Lecture


Gerard Evan, PhD, FMedSci, FRS, FAACR
Department of Biochemistry, University of Cambridge



10:30

Dissecting and Rewiring Immune Cell Heterogeneity in Brain Tumors


Leila Akkari, PhD
Netherlands Cancer Institute (NKI)
Oncode Institute




11:00

Coffee Break




11:30



12:00

Jeffrey W. Pollard, PhD
College of Medicine and Veterinary Medicine, University of Edinburgh



12:30

Lunch




13:30

Poster Session I




15:30

Altered glycosylation in the tumor microenvironment: dissecting the molecular
mechanisms and understanding the clinical implications


Celso A. Reis, PhD
Institute for Research and Innovation in Health (i3s) & Institute of Molecular Pathology and Immunology of the University of Porto , ICBAS Institute of Biomedical Sciences Abel Salazar, Institute of Molecular Pathology and Immunology of the University of Porto



15:45

Physiological relevance of Flower during metastases development


Maria Bettencourt, PhD Candidate
Champalimaud Foundation



16:00




16:30

Coffee Break




17:00

Workshop
The Evolution of Mentorship in Space and Time: How to Tailor Your Mentorship


Informal workshop session around finding and acting as a mentor throughout your working life, drawing on experiences from academics at different career stages, followed by a roundtable.

The importance of adopting mentors throughout your career and bringing some kindness into the world
Neta Erez, Tel Aviv University
 
Train yourself as a mentor: schools outreach
Adriana Sánchez-Danés and Ciência di Noz Manera mentors:

The evolution of mentorship in space and time: how to tailor your mentorship
Ana Luisa Correia, Champalimaud Foundation
Sarah-Maria Fendt, VIB-KU

Roundtable



18:30

Social
Lisbon tour and sunset drinks








︎  Time in Lisbon (WEST)



9:00

Registration




9:30

Keynote Lecture
From bedside to bench: Critical unmet needs in Oncology


Fatima Cardoso, MD
Breast Unit, Champalimaud Foundation
ABC Global Alliance




10:30

Stromal and immune plasticity shape the metastatic microenvironment


Neta Erez, PhD
Sackler Faculty of Medicine, Tel Aviv University




11:00

Coffee Break




12:00

A vascular-restricted, tumor-induced neutrophil population drives vascular occlusion, pleomorphic necrosis, and metastasis


Jose M. Adrover, PhD
Cold Spring Harbor Laboratory




12:15

Bone Marrow Niche Dynamics and Metastatic Dormancy


Alexander Schäffer, PhD Candidate
Georg-Speyer-Haus - Institute for Tumor Biology and Experimental Therapy





13:00

Lunch




14:00

Poster Session II 




16:00

Metabolic rewiring driving metastasis formation


Sarah-Maria Fendt, PhD

VIB-KU Leuven Centre for Cancer Biology



16:30

Cédric Blanpain, PhD
Université Libre de Bruxelles
Laboratory of Stem Cells and Cancer




17:00

Coffee Break




17:30

Keynote Lecture


Joan Massagué, PhD
MSKCC - Memorial Sloan Kettering Cancer Centre




18:30

Closing Remarks




19:00

Social
Boat tour




20:00

Social
Banquet









Poster Session I

Thu 20 Oct

13h30–15h30, Lisbon time


1

Metastatic colorectal carcinoma-associated fibroblasts display an IGFBP2-dependent immunosuppressive effect on the tumour microenvironment


Cristiano Ramos, Department of General Surgery, Division of Visceral Surgery, Medical University of Vienna, et al.



2

Intra-Hospital Virtual Communities structure: impact on Patient Well-Being and in the Relationship with Physicians and Institutions


Ricardo Jorge Mendes da Silva, Faculty of Economics of University of Porto, Portuguese Institute of Oncology of Porto, et al.



3

Development and Characterization of Ovarian Cancer Zebrafish Avatars


Filipa Amorim, Champalimaud Foundation, et al.



4

Dendritic cells, bridging neuromodulation and immunity


Raquel Pessoa-Silva, Champalimaud Foundation, et al.



5

Study of immune-epithelial crosstalk using an innovated 3D culture system


Michelle Miniter, University of Cambridge, et al.



6

PLK4 potentiates anoikis-resistance of p53KO epithelial cells through P-cadherin upregulation in the tumor microenvironment


Irina Fonseca, Instituto Gulbenkian de Ciência (IGC) & Instituto de Investigação e Inovação em Saúde (i3S), Cancel Stem, Portuguese Consortium on Cancer Stem Cells, et al.



7

Dissecting intra-tumor clonal dynamics and its crosstalk with the microenvironment in a zebrafish xenograft model


Vanda Póvoa, Champalimaud Foundation, et al.



8

Novel players involved in Flower-mediated cell competition


Catarina Marçal-Costa, Champalimaud Foundation, et al.



9

Osteosarcoma-derived secretome modulate the lung microenvironment and accelerate lung metastasis formation


Sara F.F. Almeida, CIBIT/ICNAS - Institute for Nuclear Sciences Applied to Health, et al.



10

Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier permeability during the pre-metastatic niche formation


Liliana Santos, CIBIT/ICNAS – Institute for Nuclear Sciences Applied to Health, et al.



11

Deciphering the impact of cancer cell’ secretome and Its derived peptides on breast cancer brain metastasis


Rita de Carvalho, i3S – Instituto de Investigação e Inovação em Saúde, IPATIMUP – Instituto de Patologia e Imunologia Molecular, ICBAS- Instituto de Ciências Biomédicas Abel Salazar, et al.



12

Glycoprotein-A repetition predominant, a target of interest for SPECT imaging of triple negative breast cancer


Alexanne Bouchard, Centre George-François Leclerc, et al.



13

Low doses of ionizing radiation modulate the pre‐metastatic niche and induce metastasis development.


Paula Oliveira, Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, et al.



14

Evolution of the mutational landscape of human healthy and precancerous oral epithelium – a role for NOTCH1


Inês Ferreira, University of Cambridge, et al.



15

RIPK3 in the interface of immunogenic cell death and microenvironment in hepatocellular carcinoma


André Cardador, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, et al.



16

Premalignant cells: should I stay (and expand) or should I go (and survive)?


Catarina Brás-Pereira, Champalimaud Foundation, et al.



17

Human bladder epithelioids


Jose A Valverde-Lopez, University of Cambridge, et al.



18

Impact of LAMA2-deficiency in cancer


Ana Sofia Lopes, cE3c-CHANGE, Faculdade de Ciências da Universidade de Lisboa and Centro Hospitalar de Lisboa Ocidental (CHLO), et al.



19

Characterization of cell competition between cancer cells and hepatocytes


Andrea Spinazzola, Champalimaud Foundation, et al.



20

Vα7.2 + Mucosal-associated invariant T cells from PDAC recognize autologous tumor cells


Jéssica Oliveira Kamiki, Champalimaud Foundation, et al.



21

Molecular phenotyping of Prostate Cancer microenvironment, with emphasis in fibroblast activation and macrophage polarization


Inês Pontinha, Champalimaud Foundation, et al.



22

Are you talking to me? How multiple myeloma-derived extracellular vesicles reprogramme the bone marrow immune niche


Raquel Lopes, Champalimaud Foundation and Faculty of Medicine of Lisbon, et al.



23

Identification of new key players of cell competition in a colon cancer model


Ana C. Queirós, Champalimaud Foundation, et al.



24

Uncovering the similarities and differences between paediatric and adult melanoma


Sofia Carvalho-Marques, Champalimaud Foundation, et al.



25

Ikebana, a novel player in Cell Competition


Mariana Reis, Champalimaud Foundation, et al.



26

Role of Azot upon Damage.


Andrés Gutiérrez, Champalimaud Foundation, et al.



27

PTMA interacts with Flower “Win” isoform promoting cancer growth and invasion


Denise Camacho, Champalimaud Foundation, et al.



28

The Molecular and Transgenic Tools Platform at Champalimaud Foundation


Ana Raquel Tomás, Champalimaud Foundation, et al.

Poster Session II
Fri 21 Oct

14h - 16h, Lisbon time


29

Evaluation of molecular changes in patients with coloretal cancer (CRC) and applicability in the liquid biopsy technique


Bianca Gomes Fernandes, Centro de Tecnologia em Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, et al.



30

Precision nanomedicine-based immunotherapy to overcome immunosuppression against metastatic melanoma


Bárbara Carreira, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, et al.



31

Innate neuroimmune interactions in pancreatic cancer


Sara T. Correia, LiMM Therapeutics and Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, et al.



32

X-ray and spectroscopic investigation of the prostate cancer tissue environment


Sarah Gosling, School of Chemical and Physical Sciences, Keele University, et al.



33

Fishing for new immunotherapy compounds to boost innate-tumor rejection


Ana B. Machado, Champalimaud Foundation, et al.



34

The prognostic value of the Sialyl-Tn biomarker in triple negative breast cancer


Rita Adubeiro Lourenço, UCIBIO, Departamento Ciências da Vida, NOVA School of Science and Technology, NOVA University of Lisbon, Associate Laboratory i4HB - Institute for Health and Bioeconomy, School of Science and Technology, NOVA University, et al.



35

Development of Glioblastoma zebrafish xenograft model


Márcia Fontes, Champalimaud Foundation, et al.



36

The influence of tumor microenvironment on the effects induced by cannabidiol when combined with exemestane in estrogen receptor-positive breast tumors


Cristina Ferreira Almeida, UCIBIO.REQUIMTE, Faculty of Farmacy, University of Porto, et al.



37

Zebrafish Avatar model towards personalised Breast Cancer therapy


Raquel Mendes, Champalimaud Foundation, et al.



38

The role of aberrant glycosylation in gastric cancer extracellular vesicles


José Pires, i3s, IPATIMUP, Faculty of Medicine of the University of Porto, et al.



39

The role of extracellular vesicles carrying cancer-associated glycans in intercellular communication


Daniela Freitas, i3S-Institute for Research and Innovation in Health, University of Porto & IPATIMUP -Institute of Molecular Pathology and Immunology, University of Porto & Departments of Pediatrics, Weill Cornell Medicine, et al.



40

Cancer Research and the Champalimaud Fish Platform


Joana Monteiro, Champalimaud Foundation, et al.



41

Unleashing natural killer (NK) cells to promote anti-tumour immunity


Ioanna Tsoukala, Georg-Speyer-Haus- Institute for Tumor Biology and Experimental Therapy, et al.



42

Lactate and immune-editing in TIL from patients with GI cancer


Frederico Mateus, Champalimaud Foundation, et al.



43

TIL expansion and T-cell function edited by pH


Bernardo Marinheiro, Champalimaud Foundation, et al.



44

TCRcloud: a screening tool for biologically and clinically relevant TCR repertoire landscapes 


Eric de Sousa, Champalimaud Foundation, et al.


45

Tumor – reactive γδ+ TILs from patients with epithelial cancer


Joana R. Lérias, Champalimaud Foundation, et al.



46

Ovarian cancer Zebrafish Avatars for personalized multiple drug testing


Marta F. Estrada, Champalimaud Foundation , et al.



47

Human tumor-infiltrating lymphocyte reactivity against pancreatic cancer epitopes is modulated by interleukin 12


Carolina M. Gorgulho, Champalimaud Foundation, et al.



48

Tumor Infiltrating Lymphocytes are activated by Shingosine-1-phosphate


Patrícia Alexandra António, Champalimaud Foundation, et al.



49

Location of Tumor Infiltrating Lymphocytes within the Tumor Microenvironment is associated with ‘young’ and tumor-reactive TIL populations


Rodrigo Eduardo, Champalimaud Foundation, et al.



50

Establishment of a Personalized 3D Ex Vivo Model for Multiple Myeloma


Diana Lourenço, Champalimaud Foundation, et al.



51

Compound Screening in a 3D Spheroid Model Identifies Curcumin Analog as a Colorectal Cancer Stem Cell Inhibitor


Vanda Marques, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon , et al.



52

Charaterisation of the colon adenocarcinoma microenvironment with a focus on natural killer cells


Hasti Calá, Champalimaud Foundation, et al.


This symposium is supported by QuantOCancer Project funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement Nº 810653.